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Model of Psychosis Onset in Schizophrenia. Symptom severity, as indicated on the y-axis, is lower in the earlier than later stages of the disease, as indicated by the x-axis. Source: Fusar-Poli P, et al., JAMA Psychiatry. 2013;70(1):107-120. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1567609486641-Q94Y12GXIMW7J7IWUQUI/Diathesis-Stress-Model-Psychosis-Final.jpeg Research Priorities for Mittal Lab Figure 2. Mittal & Walker, 2019 https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/a1473441-755d-424a-9465-42b9ed644047/Picture2.jpg Research Priorities for Mittal Lab - Make it stand out Vargas & Mittal, Annual Rev Dev Psychol, 2022. Expanding the diathesis-stress model (see Figure 3a) to consider early development as well as dynamic and multifaceted environments, stressors, and systemic factors. Abbreviations: ACTH, adrenocorticotropic hormone; DHEA, dehydroepiandrosterone; DHEA-S, dehydroepiandrosterone sulfate; HPA, hypothalamus-pituitary-adrenal; HPG, hypothalamic-pituitary-gonadal. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1450374977625-AUU2WLMGI2FJKIMP475J/image-asset.png Research Priorities for Mittal Lab Figure 3b. Normal cortical development involves proliferation, migration, arborization, and myelination, with the first two processes occurring mostly during prenatal life and the latter two continuing through the first two post-natal decades. The combined effects of pruning of the neuronal arbor and myelin deposition are thought to account for the progressive reduction of grey-matter volume observed with longitudinal neuroimaging. Beneath this observed overall reduction, local changes are far more complex. . b. The trajectory in children developing schizophrenia could include the reduced elaboration of inhibitory pathways and excessive pruning of excitatory pathways leading to altered excitatory-inhibitory balance in the prefrontal cortex. Reduced myelination would alter connectivity. Detection of prodromal neurodevelopmental changes could permit early intervention with potential prevention or preemption of psychosis. Source: Insel, 2010 (appearing in Nature) https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1464059708567-9ZB39OOFJOWAAP3G2SIT/image-asset.png Research Priorities for Mittal Lab Figure 5. Basal ganglia loops are relevant for significantly more than motor behavior. Loops are integral for governing executive function, motivation/reward, and personality (Obeso et al., 2014, Lancet). https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1500072410863-B2DSA3BPL18A1UET8U1X/image-asset.jpeg Research Priorities for Mittal Lab Basal ganglia, cerebellar, and cortical loops govern motor behaviors, and dysfunction across these circuits is implicated in the pathophysiology of psychosis. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1464060586646-Y1SCAZGB51M1EHF6ULJI/image-asset.png Research Priorities for Mittal Lab Figure 6. Participants in the ultra high-risk group show increased sway area when compared to controls. Our lab uses a highly sensitive multiaxial postural control device. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1500075693344-4JRGWR0T41TTTIVY5V50/image-asset.png Research Priorities for Mittal Lab Figure 7. We adapted a force variability task utilizing polymer rods and air pressure for use inside the scanner (with the help of Randy O'Reilly and his team). This fMRI task has helped us to understand frontal-striatal contributions to deficits in motor control. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1448771295931-O8YLFCGATKQUVIZZGHRP/image-asset.png Research Priorities for Mittal Lab Figure 8. Exercise Model of Psychosis: Mittal https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1500320990929-1RLJ3S7GPYQ2N1OHACN2/image-asset.jpeg Research Priorities for Mittal Lab Figure 10. Familiarity may not lead to a habituated neural response over time in youth at-risk for psychosis and this may contribute to broader functional impairments. (Osborne..Mittal, 2021, JoPaCS) https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1506195328086-ACBSG939ELT57YQ7VRV6/Untitled.jpeg Research Priorities for Mittal Lab Figure 9. Dyadic interaction study rationale https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1477462305779-JG5ULJCM1H3UGKLV2F10/image-asset.jpeg Research Priorities for Mittal Lab Figure 11a. Lab members Tina Gupta and Katherine Damme perform pre-processing and quality checks utilizing the lab’s graphics workstation. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1500192253616-RC80H7DVHPWVWI8ERXHI/image-asset.png Research Priorities for Mittal Lab 11b Kate's project, currently under review with a great journal, examines cortical surface morphometry from several different angles. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1477462216537-5Q8KWSLFSN59623W0LA7/image-asset.jpeg Research Priorities for Mittal Lab Figure 12. Depicts Cerebellar tDCS that is applied in an ongoing study designed to improve implicit learning rates. http://www.adaptprogram.com/collaborators daily 0.75 2022-12-29 https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1477465130713-SYA21OKE3EC4CUV06V20/IMG_2557.jpg Mittal Lab Collaborators https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1448765316764-WGJP2GRCEA9V6RRIYJB3/image-asset.png Mittal Lab Collaborators https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1448765329740-62KBKZ8HQ6HPJJN7GVXM/image-asset.jpeg Mittal Lab Collaborators https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1448765002192-IAVOWS4AQ5OHBHTGSQNX/image-asset.gif Mittal Lab Collaborators https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1448765598546-VY2WTU29O13V1T28AJHO/image-asset.jpeg Mittal Lab Collaborators 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https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1448683981062-SGQCCS9OXFTO5DJQKIX1/image-asset.png ADAPT Lab Funding https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1553120450602-EJHIM3AKNVXNX3NXEW97/7f0630f3-4461-434b-bdb4-5f1e91a77ac3.jpg ADAPT Lab Funding https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1493010250113-Y72WLYM3ORP16ZKEQK2J/image-asset.jpeg ADAPT Lab Funding https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1448684010585-200WB7EM4HPS1244J9HK/image-asset.png ADAPT Lab Funding https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1495211895606-J8T0I7M4YM2NZL6JGR4R/image-asset.png ADAPT Lab Funding https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1471843042916-Z05Y0OK2BNWFTIS1WJG0/image-asset.png ADAPT Lab Funding https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1493010267108-1RBJH6RB9F2LB8NNNFOZ/image-asset.png ADAPT Lab Funding http://www.adaptprogram.com/mittal-lab-news daily 0.75 2025-07-24 https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1477464359859-GVDCBX4DAO4QZDGRTAX6/IMG_1357.jpg ADAPT Team News https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/b15827ad-83ea-4223-97ec-d969cd573139/IMG_0839.jpg ADAPT Team News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/0d25c12c-a85b-4df0-a039-9fd1b5aabad4/IMG_2481.jpeg ADAPT Team News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/cf4eb181-94d3-4b06-9d43-f1af9b9f96a4/IMG_1949.JPG ADAPT Team News - Make it stand out Ivanka and Vijay at graduation! https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/0173cb51-f9f0-4e90-bcee-97d0d0b45fa1/IMG_1418.PNG ADAPT 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way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1f2bb32e-e521-42a7-b14c-d1067b12f414/morgan+and+poster.jpeg ADAPT Team News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/80a17a3e-c602-4f0b-bd52-0e533f747c80/Image+%281%29.jpeg ADAPT Team News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/990fd5b3-c353-4fc3-bd46-55f1b112e88e/Image.jpeg ADAPT Team News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/62f7ccaa-2079-464f-a905-188ddcfd59a8/IMG_7160.jpg ADAPT Team News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/15b9d489-dce7-49bb-b032-0089b5139eb1/316663707_10159042031433359_3656498978426388300_n.jpg ADAPT Team News - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1609868249887-CYK8EWVMN2XP0APU72T7/Holiday+Photo+with+Border.png ADAPT Team News Happy holidays from the ADAPT team! https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1559701283925-G57R2Z5BCDNVX1AYZTZU/IMG_8276.jpg ADAPT Team News Derek and Emily get their doctorates!! https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1559155532803-4EYXQXBBQTKVZ406EGKF/nu-vijay-mittal-table2.jpg ADAPT Team News Click for news story on ADAPT lab projects!! https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1559412564886-INLIH9ZD9C4HVM07273T/IMG_3121.jpeg ADAPT Team News ADAPT Undergraduates thank their Graduate student mentors for help on projects this past few quarters! https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1544383082794-SKNO0RGJ09032PSBXYH7/IMG_1610.jpeg ADAPT Team News https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1528827020800-16NKS3ZT1GDL1VV34JCT/IMG_8902.jpg ADAPT Team News https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1515802739076-K4Z1F06TAXNC40F5CYCT/IMG_7878.jpg ADAPT Team News https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1506050032025-GXLUX5TEC67IFC7OC8T7/IMG_0348.jpg ADAPT Team News https://images.squarespace-cdn.com/content/v1/565283a3e4b06ed63ea5f928/1496422675138-AC1BPSCIMHYQEXS54E07/image-asset.png ADAPT Team News ADAPT Research Assistants Rachel Conley, Ned Shashoua, Emily Frraser and Alara Ozsan (Raffi Cowan in background) enjoy our end of the term lab party! 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