ADAPT: Active Awards
National Institute of Mental Health (NIMH) R01 120088
Project Title: CAPER: Computerized Assessment for Psychosis Risk 1R01MH120088-01A1
Principal Investigators: Jim Gold, Vijay Mittal, Lauren Ellman, Gregory Strauss, Phil Corlett/Scott Woods
Total Direct Costs: $8,125,402
Project: 4/01/2020-3/30/2025
Co-Is: Elaine Walker, Steve Silverstein, Albert Powers, Rick Zinbarg, Shou Chen
Goal: To examine the value of including markers sensitive to disease course and amenable to computational approaches and utilize these to develop a new computerized battery for risk assessment of youth at clinical high-risk for psychosis.
National Institute of Mental Health, R01MH112545
Project Title: 2/3 Community psychosis risk screening: An instrument development study
Principal Investigators (MPIs): Vijay Mittal, Lauren Ellman, Jason Schiffman
Project Period: 7/2017-7/2024 (NCE)
Total Direct Costs: $2,500,000.00
Co-Is: Thomas Olino, Waren Bilker
Goal: This study, including sites in at Northwestern, Temple, and UMBC, will recruit twelve thousand adolescents and young adult participants with aims to develop a brief screening instrument (consisting of face valid symptoms as well as less direct, but conceptually relevant, target variables) designed to identify non-help seeking youth in the community who are likely to benefit from further specialized assessments of psychosis risk (e.g., structured clinical interviews).
National Institute of Mental Health R01
Project Title: Motor features of the voice as indicators of psychomotor agitation and retardation in current and remitted MDD
Principal Investigators (MPI): Stewart A. Shankman, Vijay A Mittal, Matthew Goldrick
Project Period: 4/2024-3/2029
Total Direct Costs: 2.5 million
Co-Is: Yosi Keshet, Sebastian Walther
Goal: Examine vocal features as a biomarker for motor symptoms and disease progression in affective disorders.
National Institute of Mental Health R01MH116039-01A1
Project Title: Prodromal Inventory for Negative Symptoms: Development and Validation
Principal Investigators (MPI): Greg Strauss, Vijay Mittal
Project Period: 3/01/2019-11/30/2024
Total Direct Costs: $2,458,416
Co-Is: Elaine Walker, Brain Kirkpatrick, Bill Horan, Paul Grant, Rick Zinbarg
Goal: To develop a highly sensitive inventory for detecting early negative symptomatology in youth at risk for psychotic disorders
National Institute of Mental Health R01 MH118741
Project Title: An examination of psychomotor disturbance in current and remitted MDD: An RDoC Study
Principal Investigators (MPIs): Stewart Shankman, Vijay Mittal, Sebastian Walther
Total Direct Costs: $2,500,000.00
Project Period: 4/1/2019-3/31/2024
Co-Is: Jessica Bernard, Alex Leow
Consultant: Vinod Menon
Goal: To study motor symptoms in depression from RDoC Framework, and to develop a mobile platform for utilizing these markers as an early identification/treatment decision informatics system.
National Institute of Mental Health (NIMH) U01 MH124639-01
Project Title: Psychosis-risk outcomes network: ProNET
Principal Investigators: Scott Woods (Yale), Carrie Bearden (UCLA), John Kane
Site PIs: Vijay Mittal (Northwestern), Fred Sabb (Oregon), William Stone (Harvard, Shanghai), Barbara Cornblatt (Northwell), Diana Perkins (UNC), Kristin Caadenhead (UCSD), , Jean Addington, (Calgary), Daniel Mathalon (UCSF), Monica Calkins/Daniel Wolf (Penn), Cheryl Corcoran, Mt. Sinai, Leslie Horton (Pittsburgh), Jason Schiffman (UMBC), Laruen Ellman, (Temple), Greg Strauss (UGA), Daniel Mamah (Washington University), Jimy Choi, Godfrey Pearlson (Hartford), , Jai Shah (Montreal), Paolo Fusar-Poli (Kings College, Pavia), Celso Arango (Madrid), Jesus Perez (Cambridge), Nikos Koutsouleris (Munich), Jun Soo Kwon (Seoul).
Co-Is: Stewart Shankman
Proposed Project Period: 9/1/20-8/2025
Total Direct Costs: 55 million (Northwestern Site Directs: 1.24 million)
Goal: Develop a treatment development network capable of examining treatment related biomarkers as well as mapping in-depth clinical outcome measures.
Brain Behavior Research Foundation Independent Investigator Award. (NARSAD)
Title: Brain stimulation targeting cerebellar-cortical circuits and verbal working memory in psychosis
Project Period: : 3/15/2018-3/14/2023 (NCE)
Co-Investigators: Jessica Bernard
Total Direct Costs: $100,000
Goal: A functional magnetic resonance imaging (fMRI), double-blind cross over study designed to determine if targeted cerebellar brain stimulation will normalize brain activation and behavioral task performance in individuals with schizophrenia performing a verbal working memory task
National Institute of Mental Health R01
Title: Social Processing Deficits in Remitted Adolescent Depression
Project Period: 12/4/19-12/3/24
PA: PA-18-484
MPI: Corresponding PI: Randy P. Auerbach; PI: Stewart A. Shankman
Co-Investigators: Vijay Mittal; Jürgen Kayser; Laura Mufson; Linda Valeri; Nicholas Allen
Total Direct Costs: 2.5 Million
Goal: Examine several modalities of social processing, including a novel eye-tracking gestures social perception task
Project Title: Brain stimulation targeting cerebellar-cortical circuits and verbal working memory in psychosis
Mentored Awards
National Institute of Mental Health Mentored Patient-Oriented Research Career Development Award K23MH129607
Project Title: Clarifying the Role of Psychomotor Retardation in Reward-Based Reinforcement Learning Deficits in MDD: A Computational and fMRI Study
PI: Allison Letkiewicz 2022-2027
Mentors: Shankman, Mittal
Goal: To examine the impact of psychomotor slowing on reward-based reinforcement learning in depression
Brain and Behavior Research Foundation, NARSAD Young Investigator Award
Project Title: Elucidating the Role of Abnormal Motor Resonance in Social Cognition Deficits in Schizophrenia
Principle Investigator: Jerillyn Kent
Project Period: 12/2017-11/19
Total Direct Costs: $60,000
Sponsors: Scott Sponheim
Collaborator: Vijay Mittal
Goal: Evaluate the intersection between motor and social functioning deficits in psychosis.
Brain and Behavior Research Foundation, NARSAD Young Investigator Award
Title: Emotion, Mental Health, and Epigenetic clock in high-risk caregivers
Principle Investigator: Claudia Haase
Project Period: 12/2017-11/23 (NCE)
Total Direct Costs: $60,000
Goal: To determine how negative emotion during dyadic interaction predicts accelerated epigenetic aging in caregivers of youth at risk for psychosis.
Sponsors: Nina Alexander. Vijay Mittal
Canadian Institutes of Health Research (CIHR), Doctoral Foreign Study Award
Project Title: Cortical Midline Structures and Self-Reflection in youth at ultra-high risk for psychosis
Principle Investigator:Raffles Cowan
Dates: 9/2017-8/2020
Mentors: Dan McAdams, Vijay Mittal
National Academy of Science, Ford Fellowship
Project Title: Early life stress and adult brain structure and cognition
Principle Investigator:Teresa Vargas
Project Period: 6/2019-5/2022
Mentor: Vijay Mittal
Goal: To examine how early experiences shape brain development and influence the way people interact with the world they live in.
NIMH National Research Service Award
Project Title: Cumulative environmental risk exposure in youth at clinical high-risk for psychosis
Principle Investigator: Teresa Vargas
Project Period: 2019-2022
Mentor: Mittal, McDade
Goal: To examine if stress during different developmental periods influences adult brain dysfunction and psychosis risk.
NIMH National Research Service Award
Project Title: Neurocorrelates of alterations in facial expressivity in youth at clinical high-risk for psychosis
Principal Investigator: Tina Gupta 2019-2021
Mentor: Mittal, Haase
Goal: To examine underlying neural circuitry in motor and limbic networks of alterations in facial expressivity in psychosis risk.
Brain Behavior Research Foundation: NARSAD Young Investigator Award
Project Title: Cerebello Prefrontal Involvement in Error Processing and Rule Learning in Youth at Ultra High-Risk for Psychosis
Principle Investigator Jessica Bernard, Ph.D.
Project Period: 1/1/2015-1/1/2017
Total Direct Costs: $60,000
Mentor: Vijay Mittal, Ph.D. Co Mentor: Banich
National Research Service Award (NRSA), 1F31MH100821-01A1
Project Title: The neural basis of social cognition in adolescence
Project Period: 10/01/2013-9/30/2016
Principle Investigator Andrea Pelletier, M.A.
Mentor: Vijay Mittal, Ph.D. Co-Mentors: Tor Wager, Jessica Turner
National Research Service Award (NRSA) 1F32MH102898-01
Project Title: Cerebellar contributions to disease course in youth at high-risk of psychosis
Project Period: 10/01/2013-9/30/2015
Principle Investigator: Jessica Bernard, Ph.D.
Mentor: Vijay Mittal, Ph.D. Co-Mentor: Marie Banich, Jessica Turner
Past Awards
National Institute of Health, R01MH094650
Project Title: Frontal-Subcortical Development, Movement Abnormalities, and Risk for Psychosis
Principal Investigator: Vijay A. Mittal, Ph.D.
Project Period: 06/01/2011-02/29/2018
Total Direct Cost: $1,820,544
Co-Is: Randal Ross, M.D., Marie Banich Ph.D., Mark Brown Ph.D.
Goal: Investigate spontaneous movement abnormalities as a potential biomarker for white matter and grey matter development components of frontal-subcortical circuits, in adolescents at high-risk for psychosis.
National Institute of Mental Health Translational Research for the Development of Novel Interventions for Mental Disorders: R21/R33 Award, MH103231
Project Title: Exercise and markers of medial temporal health in youth at ultra high-risk for psychosis.
Principal Investigators (MPIs): Vijay Mittal, Ph.D., Angela Bryan
Project Period: 07/2014-6/2020
Total Direct Costs: $850,000
Co-I: Randal Ross, M.D.
Goal: To test feasibility and to design a pilot controlled trial investigation of cardiovascular exercise and medial temporal neurogenesis and cognitive/functioning remediation in youth at high risk for schizophrenia.
National Institute of Mental Health R21 MH119677
Project Title: Language features and High-Risk Psychosis Youth
Principal Investigators: Matthew Goldrick, Vijay A Mittal
Project Period: 4/2019-12/30/2022
Total Direct Costs: $275,000
Goal: Project will examine vocal features from the perspective that they may represent a sign of motor dysfunction in youth at high risk for psychosis. We will use a computational approach through linguistic feature and pattern analysis and follow high-risk youth over time to track course and develop predictive models.
National Institute of Mental Health R21 MH110374
Project Title: Neural Habituation in Ultra High-Risk Youth
Principal Investigator: Vijay Mittal, Ph.D.
Project Period: 04/2017-3/2020 (NCE)
Total Direct Costs: $275,000
Co-Is: Tim Curran, Ph.D., Holly Earls, Ph.D.
Goal: Evaluate timing of affective recognition deficits in youth at clinical high risk for psychosis.
National Institute of Mental Health R21 MH115231
Project Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction
Principal Investigators: Claudia Haase, Vijay A. Mittal
Project Period: 9/2017-8/30/2022 (NCE)
Total Direct Costs: $275,000
Goal: Project will examine adolescents at high-risk for psychosis and caretakers in a dyadic interaction task to evaluate if patterns of aberrant emotional arousal and regulation predict course of illness.
CHP-R SAMSHA Federal Grant SM-18-012
Title: Community Programs for Outreach and Intervention with Youth and Young Adults at Clinical High Risk for Psychosis
Total Direct Costs: $1,600,000
PIs: State of Illinois, Thresholds
Project Period: 12/2018-11/2022
Consultant: Mittal, Hooker
Goal: To implement a stepped care model to treatment of prodromal syndromes in the Illinois healthcare system.
Buffett Institute for Global Study, Scholars in Israel Collaboration
P.Is Matthew Goldrick, Vijay Mittal, Emily Cibelli, Joseph Keshet, Yossi Adi, Jennifer Cole
Date: 06/2017-5/2017
Total Award: $25,000
Title: A Multidisciplinary Approach to Predicting Schizophrenia
Goal: To use machine learning to evaluate movement markers of risk for psychosis.
Northwestern Weinberg College Research and Innovation Grant (W Award)
Project Title: Using motor control disruptions in speech to predict risk for psychotic disorders
Principle Investigator: Emily Cibelli, Matthew Goldrick (Department of Linguistics); Vijay Mittal
Direct Costs: $35,000
Project Period: 9/2017-8/2018
Goal: To develop software for analyzing speech patterns indicating increased risk for psychosis.
Northwestern Data Science Initiative Award
Project Title: Automated analysis of vocal characteristics for early detection of schizophrenia
Project Period: 06/2016-05/2017
Principle Investigator: Emily Cibelli, Ph.D. Matthew Goldrick, Ph.D. Vijay Mittal, Ph.D.
Total Direct Costs: $30,000
Goal: To Evaluate early motor dysfunction in speech signifying risk for psychosis.
Intermountain Neuroimaging Consortium (INC) Pilot Award
Project Title: Default Mode Network Hyperconnectivity Across theSchizophrenia Spectrum
PI: Vijay Mittal and Jessica Turner
Project Period: 2012-2013
Goal: To examine potential hyperconnectivity patterns across the psychosis spectrum
National Institute of Health (NIH) Clinical Research Loan Repayment Award (2009-2012) NIH- L30 MH087258:01-02
Project Title: Dyskinetic Movements and Glucocorticoids in Adolescents At-Risk for Psychosis
Principal Investigator: Vijay A. Mittal, Ph.D.
Goal: This project is designed to investigate the roles between stress reactivity, reciprocal dopamine activation, and potentially consequent neuromotor dysfunction
National Institute of Mental Health (NIMH) National Research Service Award (NRSA)/Training NIMH NRSA T32 MH14584-33
Principal Investigator: Keith Nuechterlein, Ph.D., University of California Los Angeles, Department of Psychology
Role: Postdoctoral Fellow
