ADAPT: Active Awards

National Institute of Mental Health, R01MH112545                                                                   Project Title: 2/3 Community psychosis risk screening: An instrument development study   Principal Investigators (MPIs): Vijay Mittal, Lauren Ellman, Jason Schiffman                       Project Period: 7/2017-7/2022                                                                                   Total Direct Costs: $2,500,000.00                                                                                                Co-Is: Thomas Olino, Waren Bilker                                                                                                  Goal: This study, including sites in at Northwestern, Temple, and UMBC, and will recruit twelve thousand adolescents and young adult participants with aims to develop a brief screening instrument (consisting of face valid symptoms as well as less direct, but conceptually relevant,  target variables) designed to identify non-help seeking youth in the community who are likely to benefit from further specialized assessments of psychosis risk (e.g., structured clinical interviews).

National Institute of Mental Health R01 MH118741 Project Title: An examination of psychomotor disturbance in current and remitted MDD: An RDoC Study Principal Investigators (MPIs): Stewart Shankman, Vijay Mittal, Sebastian Walther Total Direct Costs: $2,500,000.00 Project Period: 2/1/2019-1/31/2024 Co-Is: Jessica Bernard, Alex Leow Consultant: Vinod Menon Goal: Study motor symptoms in depression from RDoC Framework, and develop a mobile platform for utilizing these markers as an early identification/treatment decision informatics system.

National Institute of Mental Health Translational Research for the Development of Novel Interventions for Mental Disorders: R21/R33 Award, MH103231                                               Project Title: Exercise and markers of medial temporal health in youth at ultra high-risk for psychosis.                                                                                                                                              Principal Investigators (MPIs): Vijay Mittal, Ph.D., Angela Bryan                                                  Project Period: 07/2014-6/2019                                                                                                        Total Direct Costs: $850,000                                                                                                             Co-I: Randal Ross, M.D.                                                                                                                   Goal: To test feasibility and to design a pilot controlled trial investigation of cardiovascular exercise and medial temporal neurogenesis and cognitive/functioning remediation in youth at high-risk for schizophrenia.

National Institute of Mental Health R21 MH110374                                                               Project Title: Neural Habituation in Ultra High-Risk Youth                                                       Principal Investigator: Vijay Mittal, Ph.D.                                                                                   Project Period: 04/2017-3/2019                                                                                                        Total Direct Costs: $275,000                                                                                                               Co-Is: Tim Curran, Ph.D., Holly Earls, Ph.D.                                                                                     Goal: Evaluate timing of affective recognition deficits in youth at clinical high-risk for psychosis.

National Institute of Mental Health R21  MH115231                                                              Project Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction                       Principal Investigators: Claudia Haase, Vijay A. Mittal                                                            Project Period: 9/2017-8/30/2019                                                                                                Total Direct Costs: $275,000                                                                                                      Goal: Project will examine adolescents at high-risk for psychosis and caretakers in a dyadic interaction task to evaluate if patterns of aberrant emotional arousal and regulation predict course of illness.

CHP-R SAMSHA Federal Grant SM-18-012 Title: Community Programs for Outreach and Intervention with Youth and Young Adults at Clinical High Risk for Psychosis Total Direct Costs: $400,000 PIs: State of Illinois, Thresholds Project Period: 12/2018-11/2022 Consultant: Mittal, Hooker Goal: To implement a stepped care model to treatment of prodromal syndromes in the Illinois healthcare system.    

National Institute of Mental Health R21, Supplement                                                              Project Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction                  Principal Investigators: Haase, Mittal                                                                                         Project Period: 9/2017-8/30/2019                                                                                                Total Direct Costs: $30,000                                                                                                           Goal: To evaluate interactive variables from dyads of care-taker/youth in the context of clinical course.

Brain Behavior Research Foundation Independent Investigator Award. (NARSAD)                  Project Title: Brain stimulation targeting cerebellar-cortical circuits and verbal working memory in psychosis                                                                                                                          PI: Vijay Mittal, Ph.D.                                                                                                                         Project Period: 9/15/2017-8/2019                                                                                                        Total Direct Costs: $99,000                                                                                                            Co-I: Jessica Bernard                                                                                                                     Goal: A functional magnetic resonance imaging (fMRI), double-blind cross over study designed to determine if targeted cerebellar brain stimulation will normalize brain activation and behavioral task performance in individuals with schizophrenia performing a verbal working memory task.         

Current Mentored & Sponsored Awards

Brain and Behavior Research Foundation, NARSAD Young Investigator Award                Project Title: Elucidating the Role of Abnormal Motor Resonance in Social Cognition Deficits in Schizophrenia                                                                                                                             Principle Investigator: Jerillyn Kent                                                                                            Project Period: 12/2017-11/19                                                                                                            Total Direct Costs: $60,000                                                                                                    Sponsors: Scott Sponheim                                                                                                  Collaborator: Vijay Mittal                                                                                                                    Goal: Evaluating the intersection between motor and social functioning deficits in psychosis.       

Brain and Behavior Research Foundation, NARSAD Young Investigator Award                  Title: Emotion, Mental Health, and Epigenetic clock in high-risk caregivers                         Principle Investigator: Claudia Haase                                                                                        Project Period: 12/2017-11/19                                                                                                            Total Direct Costs: $60,000                                                                                                            Goal:  To determine how negative emotion during dyadic interaction predicts accelerated epigenetic aging in caregivers of youth at risk for psychosis.                                               Sponsors: Nina Alexander. Vijay Mittal

Canadian Institutes of Health Research (CIHR), Doctoral Foreign Study Award                Project Title: Cortical Midline Structures and Self-Reflection in youth at ultra-high risk for psychosis                                                                                                                                        Principle Investigator:Raffles Cowan                                                                                           Dates: 9/2017-8/2020                                                                                                                    Mentors: Dan McAdams, Vijay Mittal

Past Awards

National Institute of Health, R01MH094650                                                                              Project Title: Frontal-Subcortical Development, Movement Abnormalities, and Risk for Psychosis                                                                                                                                    Principal Investigator: Vijay A. Mittal, Ph.D.                                                                                        Project Period: 06/01/2011-02/29/2018                                                                                         Total Direct Cost: $1,820,544                                                                                                            Co-Is: Randal Ross, M.D., Marie Banich Ph.D., Mark Brown Ph.D.                                                     Goal: Investigate spontaneous movement abnormalities as a potential biomarker for white matter and grey matter development components of frontal-subcortical circuits, in adolescents at high-risk for psychosis.

Buffett Institute for Global Study, Scholars in Israel Collaboration                                              P.Is Matthew Goldrick, Vijay Mittal, Emily Cibelli, Joseph Keshet, Yossi Adi, Jennifer Cole         Date: 06/2017-5/2017                                                                                                                       Total Award: $25,000                                                                                                                         Title: A Multidisciplinary Approach to Predicting Schizophrenia                                                            Goal: To use machine learning to evaluate movement markers of risk for psychosis.

Northwestern Weinberg College Research and Innovation Grant (W Award)                           Project Title: Using motor control disruptions in speech to predict risk for psychotic disorders Principle Investigator: Emily Cibelli, Matthew Goldrick (Department of Linguistics); Vijay Mittal   Direct Costs: $35,000                                                                                                                  Project Period: 9/2017-8/2018                                                                                                           Goal: To develop software for analyzing speech patterns indicating increased risk for psychosis.    

Northwestern Data Science Initiative Award                                                                                   Project Title: Automated analysis of vocal characteristics for early detection of schizophrenia   Project Period: 06/2016-05/2017                                                                                                Principle Investigator: Emily Cibelli, Ph.D.  Matthew Goldrick, Ph.D. Vijay Mittal, Ph.D.                Total Direct Costs: $30,000                                                                                                              Goal: To Evaluate early motor dysfunction in speech signifying risk for psychosis.

Intermountain Neuroimaging Consortium (INC) Pilot Award                                                 Project Title: Default Mode Network Hyperconnectivity Across theSchizophrenia Spectrum     PI: Vijay Mittal and Jessica Turner                                                                                                Project Period: 2012-2013                                                                                                               Goal: To examine potential hyperconnectivity patterns across the psychosis spectrum

National Institute of Health (NIH) Clinical Research Loan Repayment Award (2009-2012) NIH- L30 MH087258:01-02                                                                                                          Project Title: Dyskinetic Movements and Glucocorticoids in Adolescents At-Risk for Psychosis Principal Investigator: Vijay A. Mittal, Ph.D.                                                                                  Goal: This project is designed to investigate the roles between stress reactivity, reciprocal dopamine activation, and potentially consequent neuromotor dysfunction

National Institute of Mental Health (NIMH) National Research Service Award (NRSA)/Training NIMH NRSA T32 MH14584-33                                                                     Principal Investigator: Keith Nuechterlein, Ph.D.                                                                  University of California Los Angeles, Department of Psychology                                             Role: Postdoctoral Fellow

Past Mentored Awards

Brain Behavior Research Foundation: NARSAD Young Investigator Award                                Project Title: Cerebello Prefrontal Involvement in Error Processing and Rule Learning in Youth at Ultra High-Risk for Psychosis                                                                                                           Principle Investigator Jessica Bernard, Ph.D.                                                                                   Project Period: 1/1/2015-1/1/2017                                                                                                          Total Direct Costs: $60,000                                                                                                                 Mentor: Vijay Mittal, Ph.D. Co Mentor: Banich

National Research Service Award (NRSA), 1F31MH100821-01A1                                                   Project Title: The neural basis of social cognition in adolescence                                                Project Period: 10/01/2013-9/30/2016                                                                                                 Principle Investigator Andrea Pelletier, M.A.                                                                            Mentor: Vijay Mittal, Ph.D. Co-Mentors: Tor Wager, Jessica Turner

National Research Service Award (NRSA) 1F32MH102898-01                                                     Project Title: Cerebellar contributions to disease course in youth at high-risk of psychosis        Project Period: 10/01/2013-9/30/2015                                                                                                  Principle Investigator: Jessica Bernard, Ph.D.                                                                                   Mentor: Vijay Mittal, Ph.D. Co-Mentor: Marie Banich, Jessica Turner