ADAPT: Active Awards
National Institute of Mental Health, R01MH112545 Project Title: 2/3 Community psychosis risk screening: An instrument development study Principal Investigators (MPIs): Vijay Mittal, Lauren Ellman, Jason Schiffman Project Period: 7/2017-7/2022 Total Direct Costs: $2,500,000.00 Co-Is: Thomas Olino, Waren Bilker Goal: This study, including sites in at Northwestern, Temple, and UMBC, and will recruit twelve thousand adolescents and young adult participants with aims to develop a brief screening instrument (consisting of face valid symptoms as well as less direct, but conceptually relevant, target variables) designed to identify non-help seeking youth in the community who are likely to benefit from further specialized assessments of psychosis risk (e.g., structured clinical interviews).
National Institute of Mental Health R01 MH118741 Project Title: An examination of psychomotor disturbance in current and remitted MDD: An RDoC Study Principal Investigators (MPIs): Stewart Shankman, Vijay Mittal, Sebastian Walther Total Direct Costs: $2,500,000.00 Project Period: 2/1/2019-1/31/2024 Co-Is: Jessica Bernard, Alex Leow Consultant: Vinod Menon Goal: Study motor symptoms in depression from RDoC Framework, and develop a mobile platform for utilizing these markers as an early identification/treatment decision informatics system.
National Institute of Mental Health Translational Research for the Development of Novel Interventions for Mental Disorders: R21/R33 Award, MH103231 Project Title: Exercise and markers of medial temporal health in youth at ultra high-risk for psychosis. Principal Investigators (MPIs): Vijay Mittal, Ph.D., Angela Bryan Project Period: 07/2014-6/2019 Total Direct Costs: $850,000 Co-I: Randal Ross, M.D. Goal: To test feasibility and to design a pilot controlled trial investigation of cardiovascular exercise and medial temporal neurogenesis and cognitive/functioning remediation in youth at high-risk for schizophrenia.
National Institute of Mental Health R21 MH110374 Project Title: Neural Habituation in Ultra High-Risk Youth Principal Investigator: Vijay Mittal, Ph.D. Project Period: 04/2017-3/2019 Total Direct Costs: $275,000 Co-Is: Tim Curran, Ph.D., Holly Earls, Ph.D. Goal: Evaluate timing of affective recognition deficits in youth at clinical high-risk for psychosis.
National Institute of Mental Health R21 MH115231 Project Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction Principal Investigators: Claudia Haase, Vijay A. Mittal Project Period: 9/2017-8/30/2019 Total Direct Costs: $275,000 Goal: Project will examine adolescents at high-risk for psychosis and caretakers in a dyadic interaction task to evaluate if patterns of aberrant emotional arousal and regulation predict course of illness.
CHP-R SAMSHA Federal Grant SM-18-012 Title: Community Programs for Outreach and Intervention with Youth and Young Adults at Clinical High Risk for Psychosis Total Direct Costs: $400,000 PIs: State of Illinois, Thresholds Project Period: 12/2018-11/2022 Consultant: Mittal, Hooker Goal: To implement a stepped care model to treatment of prodromal syndromes in the Illinois healthcare system.
National Institute of Mental Health R21, Supplement Project Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction Principal Investigators: Haase, Mittal Project Period: 9/2017-8/30/2019 Total Direct Costs: $30,000 Goal: To evaluate interactive variables from dyads of care-taker/youth in the context of clinical course.
Brain Behavior Research Foundation Independent Investigator Award. (NARSAD) Project Title: Brain stimulation targeting cerebellar-cortical circuits and verbal working memory in psychosis PI: Vijay Mittal, Ph.D. Project Period: 9/15/2017-8/2019 Total Direct Costs: $99,000 Co-I: Jessica Bernard Goal: A functional magnetic resonance imaging (fMRI), double-blind cross over study designed to determine if targeted cerebellar brain stimulation will normalize brain activation and behavioral task performance in individuals with schizophrenia performing a verbal working memory task.
Current Mentored & Sponsored Awards
Brain and Behavior Research Foundation, NARSAD Young Investigator Award Project Title: Elucidating the Role of Abnormal Motor Resonance in Social Cognition Deficits in Schizophrenia Principle Investigator: Jerillyn Kent Project Period: 12/2017-11/19 Total Direct Costs: $60,000 Sponsors: Scott Sponheim Collaborator: Vijay Mittal Goal: Evaluating the intersection between motor and social functioning deficits in psychosis.
Brain and Behavior Research Foundation, NARSAD Young Investigator Award Title: Emotion, Mental Health, and Epigenetic clock in high-risk caregivers Principle Investigator: Claudia Haase Project Period: 12/2017-11/19 Total Direct Costs: $60,000 Goal: To determine how negative emotion during dyadic interaction predicts accelerated epigenetic aging in caregivers of youth at risk for psychosis. Sponsors: Nina Alexander. Vijay Mittal
Canadian Institutes of Health Research (CIHR), Doctoral Foreign Study Award Project Title: Cortical Midline Structures and Self-Reflection in youth at ultra-high risk for psychosis Principle Investigator:Raffles Cowan Dates: 9/2017-8/2020 Mentors: Dan McAdams, Vijay Mittal
National Institute of Health, R01MH094650 Project Title: Frontal-Subcortical Development, Movement Abnormalities, and Risk for Psychosis Principal Investigator: Vijay A. Mittal, Ph.D. Project Period: 06/01/2011-02/29/2018 Total Direct Cost: $1,820,544 Co-Is: Randal Ross, M.D., Marie Banich Ph.D., Mark Brown Ph.D. Goal: Investigate spontaneous movement abnormalities as a potential biomarker for white matter and grey matter development components of frontal-subcortical circuits, in adolescents at high-risk for psychosis.
Buffett Institute for Global Study, Scholars in Israel Collaboration P.Is Matthew Goldrick, Vijay Mittal, Emily Cibelli, Joseph Keshet, Yossi Adi, Jennifer Cole Date: 06/2017-5/2017 Total Award: $25,000 Title: A Multidisciplinary Approach to Predicting Schizophrenia Goal: To use machine learning to evaluate movement markers of risk for psychosis.
Northwestern Weinberg College Research and Innovation Grant (W Award) Project Title: Using motor control disruptions in speech to predict risk for psychotic disorders Principle Investigator: Emily Cibelli, Matthew Goldrick (Department of Linguistics); Vijay Mittal Direct Costs: $35,000 Project Period: 9/2017-8/2018 Goal: To develop software for analyzing speech patterns indicating increased risk for psychosis.
Northwestern Data Science Initiative Award Project Title: Automated analysis of vocal characteristics for early detection of schizophrenia Project Period: 06/2016-05/2017 Principle Investigator: Emily Cibelli, Ph.D. Matthew Goldrick, Ph.D. Vijay Mittal, Ph.D. Total Direct Costs: $30,000 Goal: To Evaluate early motor dysfunction in speech signifying risk for psychosis.
Intermountain Neuroimaging Consortium (INC) Pilot Award Project Title: Default Mode Network Hyperconnectivity Across theSchizophrenia Spectrum PI: Vijay Mittal and Jessica Turner Project Period: 2012-2013 Goal: To examine potential hyperconnectivity patterns across the psychosis spectrum
National Institute of Health (NIH) Clinical Research Loan Repayment Award (2009-2012) NIH- L30 MH087258:01-02 Project Title: Dyskinetic Movements and Glucocorticoids in Adolescents At-Risk for Psychosis Principal Investigator: Vijay A. Mittal, Ph.D. Goal: This project is designed to investigate the roles between stress reactivity, reciprocal dopamine activation, and potentially consequent neuromotor dysfunction
National Institute of Mental Health (NIMH) National Research Service Award (NRSA)/Training NIMH NRSA T32 MH14584-33 Principal Investigator: Keith Nuechterlein, Ph.D. University of California Los Angeles, Department of Psychology Role: Postdoctoral Fellow
Past Mentored Awards
Brain Behavior Research Foundation: NARSAD Young Investigator Award Project Title: Cerebello Prefrontal Involvement in Error Processing and Rule Learning in Youth at Ultra High-Risk for Psychosis Principle Investigator Jessica Bernard, Ph.D. Project Period: 1/1/2015-1/1/2017 Total Direct Costs: $60,000 Mentor: Vijay Mittal, Ph.D. Co Mentor: Banich
National Research Service Award (NRSA), 1F31MH100821-01A1 Project Title: The neural basis of social cognition in adolescence Project Period: 10/01/2013-9/30/2016 Principle Investigator Andrea Pelletier, M.A. Mentor: Vijay Mittal, Ph.D. Co-Mentors: Tor Wager, Jessica Turner
National Research Service Award (NRSA) 1F32MH102898-01 Project Title: Cerebellar contributions to disease course in youth at high-risk of psychosis Project Period: 10/01/2013-9/30/2015 Principle Investigator: Jessica Bernard, Ph.D. Mentor: Vijay Mittal, Ph.D. Co-Mentor: Marie Banich, Jessica Turner